The most serious side effects experienced with Xarelto are: The most common side effects of Xarelto are: RELATED: What is Xarelto? | Get Xarelto discounts Common side effects of Xarelto Oral anticoagulants like Xarelto are effective for treating and preventing blood clots, but they have some side effects to be aware of. It is classified as a factor Xa inhibitor that works by blocking one of the proteins, called factor Xa (“10-A”), involved in the blood clotting process. Xarelto contains the active ingredient rivaroxaban and works to slow the formation of blood clots. Xarelto is also FDA-approved to reduce the risk of stroke and other problems from blood clots in people diagnosed with nonvalvular atrial fibrillation, coronary artery disease, or peripheral artery disease. It can also be used to prevent deep vein thrombosis in people at risk for blood clots, including people who are hospitalized with an illness and those who are undergoing hip replacement surgery or knee replacement surgery. Xarelto is a brand-name prescription oral anticoagulant used to treat deep vein thrombosis (DVT) and pulmonary embolism (PE). District Courts nationwide for individual trial dates later this year.Xarelto side effects | Serious side effects | Bleeding | Reversal | How long do side effects last? | Warnings | Interactions | How to avoid side effects Resources Each of the claims raise similar allegations that users and the medical community were not adequately warned about the risk of uncontrollable bleeding on Xarelto.įollowing a handful of early bellwether trials, which were held before Judge Fallon to help gauge how juries may respond to certain evidence and testimony that is likely to be repeated throughout the litigation, no progress has been made in negotiating Xarelto settlements or another resolution for the claims.Īs a result, Judge Fallon recently ordered the parties to select 1,200 Xarelto cases for discovery, which may then be remanded back to U.S. District Judge Eldon Fallon in the Eastern District of Louisiana. Currently, there are about 20,000 Xarelto lawsuits pending as part of a federal multidistrict litigation (MDL), which is centralized before U.S. Incidents of unstoppable bleeding have resulted in injury and death for patients using the new drugs. In addition, a 2016 study showing positive results for AndexXa (andexanet alfa) has come under scrutiny by doctors, who say that the study’s researchers may have been overstating its benefits. Portola Pharmaceuticals has been working to convince the FDA to approve AndexXa for nearly two years.įDA officials have been cautious about the reversal agent, which may be used by millions of patients, and have called for more evidence that it is safe and effective. Unlike warfarin, which can be quickly reversed with a known antidote, no approved reversal agent for Xarelto has been available since the drug was introduced in 2011. However, the two drugs have been linked to thousands of reports involving severe and fatal injuries, when users experienced bleeding that doctors were unable to stop or reverse. Xarelto and Eliquis were introduced as a replacement for warfarin as a preventative treatment for strokes and other problems associated with atrial fibrillation. Lis told investors that if the process is approved, it would then be available to about 1,000 different providers. Until the FDA approves the manufacturing process in question, AndexXa will only be provided at about 40 or 50 hospitals, and a few other locations, all of which served as clinical trial sites. However, the FDA appeared convinced enough to grant the drug’s approval last week. Lis also noted that the company is still collecting data on the bioequivalence between AndexXa made by the two different manufacturing processes.
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